您的位置: 首页 > 农业专利 > 详情页

RECEPTEUR D'ANTIGENE CHIMERE UTILISANT DES DOMAINES DE RECONNAISSANCE D'ANTIGENES DERIVES DE POISSON CARTILAGINEUX
专利权人:
CELLECTIS
发明人:
DUCHATEAU, PHILIPPE,VALTON, JULIEN
申请号:
CA2936693
公开号:
CA2936693A1
申请日:
2015.01.14
申请国别(地区):
CA
年份:
2015
代理人:
摘要:
The present invention relates to a new generation of chimeric antigen receptors (CAR), under single-chain or multi-chain forms, the specificity of which, to a desired antigen, is conferred by a VNAR polypeptide derived from monomeric antibodies from cartilaginous fish. Such CARs, which aim to redirect immune cell specificity toward selected undesired malignant cells, are compact and thus particularly adapted to target hollow antigens such as ions channels of efflux pumps present at the surface of drug-resistant cells. The invention encompasses the polynucleotides, vectors encoding said multi-chain CAR and the isolated cells expressing them at their surface, in particularly for their use in immunotherapy.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充