serine / threonine kinase inhibitors, compositions comprising them, their uses and their preparation processes, and method of inhibiting erk protein kinase activity in a cell

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专利权人:

GENENTECH, INC.;ARRAY BIOPHARMA INC.

发明人:

AIHE ZHOU,DAVID A. MORENO,HUIFEN CHEN,JACOB SCHWARZ,JAMES F. BLAKE,JOHN GAUDINO,JONAS GRINA,KIRK ROBARGE,LI REN,MARK JOSEPH CHICARELLI,PETER J. MOHR,RUSTAM FERDINAND GARREY

申请号：

BR112014021634

公开号：

BR112014021634A8

申请日:

2013.03.01

申请国别(地区):

BR

年份:

2018

代理人:

摘要：

abstract compounds of formula or stereoisomer, tautomer, pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. methods of using compounds of formula or stereoisomer, tautomer, pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. Translation of the Summary Patent Summary: "Serine / Threonine Kinase Inhibitors". compounds of formula I, or a pharmaceutically acceptable salt, stereoisomer, tautomer, prodrug or salt thereof, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases, are provided. Methods of using the compounds of formula I or a pharmaceutically acceptable stereoisomer, tautomer, prodrug or salt thereof for the diagnosis, prevention or treatment in vitro, in situ, and in vivo of such disorders are disclosed. mammalian cells, or associated pathological conditions.abstract compounds of formula i or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. methods of using compounds of formula i or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. i tradução do resumo resumo patente de invenção: "inibidores de serina/treonina cinase". proporcionam-se compostos de fórmula i, ou um seu estereoisômero, tautômero, pró-medicamento ou sal farmaceuticamente aceitável, que são úteis para o tratamento de doenças hiperproliferativas, de dor e inflamatórias. divulgam-se os métodos de utilizar os compostos da fórmula i, ou um seu estereoisômero, tautômero, pró-medicamento ou sal farmaceuticament

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