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DETERMINATION OF LEVELS OF IMMUNOGENIC GLUTEN PEPTIDES IN HUMAN SAMPLES
专利权人:
Universidad de Sevilla
发明人:
SOUSA MARTÍN, Carolina,COMINO MONTILLA, Isabel,REAL CALDERÓN, Ana,VIVAS ALEGRE, Santiago,CEBOLLA RAMÍREZ, Ángel
申请号:
EP20110852781
公开号:
EP2660593(B1)
申请日:
2011.12.28
申请国别(地区):
欧洲专利局
年份:
2018
代理人:
摘要:
The present invention relates to the medical/clinical sector and discloses a method for monitoring gluten ingestion by means of the measurement of gluten proteins/peptides in faeces using antibodies to immunogenic peptides resistant to gastrointestinal digestion. The presence or absence of said immunogenic peptides is monitored by means of immunological assays based on antibodies that react with immunogenic gluten peptides that are proteolysis-resistant. Said assays may be quantitative ELISA techniques, or qualitative assays such as rapid immunochromatographic assays, immunoblots, etc.; These measurements could also be used to verify adherence to a gluten-free diet with a view to enhancing diagnosis in cases of refractory or acute symptoms of coeliac disease in cases where a gluten-free diet is allegedly being complied with, or in the clinical investigation of the effectiveness of prolamine detoxification-related enzyme therapies..
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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