A NOVEL COMPOUND ABLE TO INHIBIT JAK IS DISCLOSED, THIS COMPOUND MAY BE PREPARED AS A PHARMACEUTICAL COMPOSITION, AND MAY BE USED FOR THE PREVENTION AND TREATMENT OF A VARIETY OF CONDITIONS IN MAMMALS INCLUDING HUMANS, INCLUDING BY WAY OF NON-LIMITING EXAMPLE, INFLAMMATORY CONDITIONS, AUTOIMMUNE DISEASES, PROLIFERATIVE DISEASES, TRANSPLANTATION REJECTION, DISEASES INVOLVING IMPAIRMENT OF CARTILAGE TURNOVER, CONGENITAL CARTILAGE MALFORMATIONS, AND/OR DISEASES ASSOCIATED WITH HYPERSECRETION OF IL6.