The Board of Trustees of the Leland Stanford Junior University
发明人:
Mehrdad Shamloo,Alam Jahangir,Bitna Yi,Andrew Kelley Evans,Michael John Green
申请号：
US16099802
公开号：
US20200237724A1
申请日:
2017.05.12
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Adrenergic receptor modulating compounds and methods of using the same are provided. Also provided are methods of treating a subject for a disease or condition associated with an adrenergic receptor including administering a therapeutically effective amount of the subject compound. Aspects of the disclosure include a method of modulating an inflammatory pathway in a cell, such as the production of TNF-alpha in the cell. The method can include contacting a cell with β1-selective adrenergic receptor modulating compound to selectively activate a cAMP pathway over a beta-arrestin pathway in the cell. Pharmaceutical compositions and kits which include the subject compounds are provided.
