De Min, Cristina,Ferlin, Walter,De Benedetti, Fabrizio
申请号：
AU2016257023
公开号：
AU2016257023A1
申请日:
2016.05.09
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
Methods and compositions for treating hemophagocytic lymphohistiocytosis (HLH) are provided. The disclosure also relates generally to methods and compositions for diagnosing and treating disorders associated with elevated levels of CXCL9, elevated levels of total IFNγ, and other biomarkers. The disclosure also relates to methods of treating, delaying the progression of, or otherwise ameliorating a symptom of a disorder in patients with elevated levels of CXCL9 elevated levels of total IFNγ, and other biomarkers using agents that interfere with or otherwise antagonize interferon gamma (IFNγ) signaling, including neutralizing anti-IFNγ antibodies.
