Refers to a Pharmaceutical composition comprising: a) an inhibitor of steroid c17,20 lyase as (+) - 6 - (4 - hydroxy - 6.7 - dihydro - 5h pyrrolo [1,2-c] imidazole - 7 - yl) - N - methyl - 2 - naphthamide and (b) a receptor agonist GnRH, GnRH receptor antagonist or a drug adrenocorticohormo Na as Leuprorelin acetate OR prednisolone.Said composition is useful in the treatment of androgen Independent Prostate CancerSE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE: A) UN INHIBIDOR DE ESTEROIDE C17,20 LIASA TAL COMO (+)-6-(7-HIDROXI-6,7-DIHIDRO-5H-PIRROLO[1,2-c]IMIDAZOL-7-IL)-N-METIL-2-NAFTAMIDA Y B) UN AGONISTA DEL RECEPTOR DE GnRH, UN ANTAGONISTA DEL RECEPTOR DE GnRH O UN FARMACO DE ADRENOCORTICOHORMONA TAL COMO ACETATO DE LEUPRORELINA O PREDNISOLONA. DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO DE CANCER DE PROSTATA INDEPENDIENTE DE ANDROGENOS