THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
发明人:
MOORE, TERRY,LAZZARA, PHILLIP,DAVID, BRIAN,RICHARDSON, BENJAMIN,JAIN, ATUL D.
申请号：
CA3095908
公开号：
CA3095908A1
申请日:
2019.04.02
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Disclosed herein are compounds that can act as inhibitors of the Kelch-like ECH- associated protein 1/nuclear factor (erythroid-derived 2)-like 2 ("KEAP1/NRF2") protein- protein interaction, and methods of using the compounds to treat and prevent diseases and disorders, such as COPD, multiple sclerosis, and diabetes, and in the promotion of wound healing. The compounds described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: formula (I), wherein the substituents are as described.
