CHEVRIER, MARC,FREIMUTH, WILLIAM,ZHONG, ZHENSHAO,ODENHEIMER, DANIEL,PERKINS, MELISSA D.
申请号：
CA2626082
公开号：
CA2626082C
申请日:
2006.10.05
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention relates to methods and compositions for use in treatmentof patients with autoantibody positive disease. In a specific embodiment, thepresent invention relates to a method of treating a patient that has an ANAtiter of 1:80 or greater and/or greater than or equal to 30 IU/ml of anti-dsDNA antibodies in his/her blood plasma or serum comprising administering atherapeutically effective amount of an immunomodulatory agent, such as anantagonist of Neutrokine-alpha. Additionally provided is a method of reducingthe frequency and/or quantity of corticosteroid administration to patients. Inpreferred embodiments, the patient has systemic lupus erythematosus. Methodsfor determining if a lupus patient is responding to medical treatment are alsoprovided.
