QUATERNARY AMMONIUM COMPOUND AND SIRNA-CONTAINING COMPOSITION AND PREPARATION METHOD THEREOF

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专利权人:

XIAMEN CHENGKUN BIOTECH CO. LTD.

发明人:

CUI, Kunyuan,崔坤元,ZHENG, Zhiling,鄭志淩,CHEN, Bo,陳波

申请号：

HK16101908.1

公开号：

HK1213811A

申请日:

2016.02.19

申请国别(地区):

HK

年份:

2016

代理人:

摘要：

The invention belongs to the field of biological medicine and particularly relates to a composition containing a quaternary ammonium salt compound and siRNA and a preparing method thereof. The composition contains a siRNA sequence and the quaternary ammonium salt compound or lipid with the function of the quaternary ammonium salt compound and can also contain phopholipid, cholesterol and lipid-polyethylene glycol. The composition containing the quaternary ammonium salt compound and siRNA can improve the pharmacokinetics characteristic of siRNA treatment, change bio-distribution, intracellular intake, targeting and transfection efficiency, and reduce adverse reaction.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/