The compounds of the formula (1) can modulate the activity of S1P receptors.Claim 1: a compound of the formula (1), where A1 is - or - ch = n =； A2 - or - ch = n =； is A3 - CH2 -, - or - ch = n =； is A4 - CH2 -, - or - ch = n = A5； IS - CH2 -, - or - ch = n =； A6 is - or - ch = n = W is； or,- or - - chr5 CR5； R5 is Hydrogen, Halo, alkyl or cycloalkyl haloalquilo； CY is a group of 4 to 7 members,A group of 4 to 7 cicloalquenilo Cy is a Member or group of members heterocicloalquenilo 4 to 7 have 1 heteroatom is or, where Cy is optionally substituted with one to four each r1；R1, independently, is Halo, alkyl, cycloalkyl, haloalquilo, hidroxialquilo, trialquilsililo, alkoxy, cicloalcoxi, cicloalcoxialquilo or alkoxyalkyl esters, aryl or two R1, taken together,Are alquileno c1-5, L1 is - C (o) - O - (2 - (R3)； each independently, R3 is Hydrogen, alkyl or haloalquilo； X is 0, 1, 2, 3, 4 or 5； and is 0, 1, 2, 3,4 or 5； where the sum of X and y is 4 or 5； each ra and RB, independently, Halo, is Hydrogen, Hydroxy, co2rc, R2 is alkyl or aryl； nco2rc - (CH2), where n is 0 OR 1； RC is Hydrogen,Haloalquilo aryl, alkyl, cycloalkyl or； provided that the compound is not acid (1 - (2 - (trans-4 - ter - butilciclohexiloxi) naftalen - 6 - yl) methyl) piperidin-4-yl carboxylicAcid (1 - (2 - (trans-4 - ter - butilciclohexiloxi) naftalen - 6 - yl) methyl) piperidin 3R - carboxylic acid or 1 - ((2 - (trans-4 - ter - butilciclohexiloxi) - 6 - naftalen 3S piperidin yl) methyl) or one of its carboxylic acid； saltsPharmaceutically acceptable.Los compuestos de la fórmula (1) pueden modular la actividad de los receptores de S1P.Reivindicación 1: Un compuesto de la fórmula (1), en donde: A1 es -CH= o -N=； A2 es -CH= o -N=； A3 es -CH2-, -CH= o -N=； A4 es -CH2-, -CH= o -N=； A5 es -CH2-, -CH= o -N=； A6 es -CH= o -N=； W es -O-, CR5- o -CHR5-； R5 es hidrógeno, halo, alquilo o haloalquilo； Cy es un grupo cicloalquilo de 4 a 7 miembros, un grupo cicloalquenilo de 4 a 7 miembros o Cy es un grupo heteroc
