Provided are an iron-based absorbable and implantable medical device and manufacturing method thereof. The iron-based absorbable and implantable medical device (1) comprises a substrate (11), a degradable polymer layer (12), and an anionic surfactant layer (13) located between the substrate (11) and the degradable polymer layer (12). The anionic surfactant, by using the hydrophobicity thereof, can form a hydrophobic barrier layer in a solution to isolate a surface of the iron-based substrate (11) from a body fluid environment, thereby avoiding direct contact with an acidic environment resulting from degradation of the degradable polymer layer (12) at the initial and early stages of implantation, thus preventing severe local corrosion of the iron-based substrate (11).
