Trisubstituted thiophene derivatives as novel, the invention is directed to their use in the treatment or prevention of disorders and diseases mediated by agonists and antagonists of the progesterone receptor as well as pharmaceutical compositions containing them. Clinical use of these compounds hormonal contraception, secondary amenorrhea, amenorrhea, dysfunctional uterine fraud bleeding, uterine fibroids, endometriosis polycystic ovary syndrome, endometrial, ovarian, breast, colon or related to the treatment and / or prevention of cancer and adenocarcinoma of the prostate. Additional use of the invention include stimulation of food intake.本発明は、新規な三置換チオフェン誘導体、それらを含有する製薬学的組成物ならびにプロゲステロン受容体のアゴニスト及びアンタゴニストにより媒介される障害及び疾患の処置又は予防におけるそれらの使用を目的とする。これらの化合物の臨床的使用はホルモン性避妊、続発性無月経、無月経、機能不全性子宮不正出血、子宮筋腫、子宮内膜症;多嚢胞性卵巣症候群、子宮内膜、卵巣、乳房、結腸又は前立腺のガン及び腺ガンの処置及び/又は予防に関する。本発明の追加の使用は、食物摂取の刺激を含む。
