Stephen Sunghan Yoo,Yong-Sik Bong,Kyu Lee Han,Michael Joseph Surace
申请号：
US16618050
公开号：
US20200131266A1
申请日:
2018.05.30
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided herein are methods for treating cancer using molecules having an antigen binding fragment that immunospecifically binds to BTN1A1, such as anti-BTN1A1 antibodies. These molecules include those having an antigen binding fragment that immunospecifically binds to glycosylated BTN1A1, such as anti-glycosylated BTN1A1 antibodies. Also included are molecules having an antigen binding fragment that immunospecifically bind to BTN1A1 dimers, such as anti-BTN1A1 dimer antibodies. Also provided are methods for treating anti-PD-1 therapy or anti-PD-L1 therapy resistant or refractory cancers.
