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DERMATOPONTIN AS A THERAPEUTIC FOR METABOLIC DISORDERS
专利权人:
发明人:
申请号:
EP16749546.4
公开号:
EP3256146A1
申请日:
2016.02.11
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
The present disclosure describes to a method of treating a metabolic disease in a subject, wherein the method comprises administration of dermatopontin to a subject, wherein the dermatopontin is recombinant dermatopontin and the metabolic disease is selected from a group consisting of weight gain, diet-induced weight gain, obesity, morbid obesity, metabolic syndrome, glucose homeostasis, insulin resistance, type I diabetes, type if diabetes and cardiovascular disease. Disclosed herein is also a method of determining or making a prognosis of a subjects susceptibility to metabolic diseases and obesity, the method comprising measuring the level of circulating dermatopontin in a sample obtained from a subject and comparing the level of circulating dermatopontin obtained with the level of dermatopontin previously determined in a control and determining the susceptibility of the subject to metabolic disease and obesity based on the difference between the level of circulating dermatopontin and the level of dermatopontin in the control.
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