ロスバスタチンカルシウムを含有する錠剤

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专利权人:

大原薬品工業株式会社

发明人:

藤井 利文,鵜飼 大

申请号：

JP2017101298

公开号：

JP6210584B2

申请日:

2017.05.23

申请国别(地区):

JP

年份:

2017

代理人:

摘要：

PROBLEM TO BE SOLVED: To provide a rosuvastatin calcium-containing tablet which is chemically stable during storage in a high humidity environment without lowering the dissolution property even if a polyvalent cationic inorganic salt stabilizer is not contained.SOLUTION: It was found that use of a certain additive in tablets containing rosuvastatin calcium prevents lactone formation and lowering of dissolution property during storage in a high humidity environment. The certain additive is a sugar alcohol (D-mannitol etc.) or a lowly substituted hydroxypropylcellulose (Example 1).SELECTED DRAWING: Figure 1

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/