您的位置:
首页
>
农业专利
>
详情页
Imidazole derivatives as inhibitors of hepatitis C virus
- 专利权人:
- BRISTOL-MYERS SQUIBB COMPANY
- 发明人:
- MAKONEN BELEMA,ZHONG YANG,JOHN A. BENDER,DENIS R. ST. LAURENT,VAN N. NGUYEN,GAN WANG,JEFFREY LEE ROMINE
- 申请号:
- ARP120104251
- 公开号:
- AR088838A1
- 申请日:
- 2012.11.09
- 申请国别(地区):
- AR
- 年份:
- 2014
- 代理人:
- 摘要:
- Compounds, compositions and Methods for the treatment of infection by the hepatitis C virus (HCV). Also Pharmaceutical compositions containing such compounds and Methods of using such compounds in the treatment of hcv infection.Claim 1, characterized in that: a compound is selected from: (R, S, r, (1S, 2S) - (1S, 2S), 5S, 5S) - 5 - (5 - (1,1 - Diphenyl - [] - diyl bis (4,4) - 1H imidazole - diyl bis (5.2) 2 - metilpirrolidin - 5.1 - diyl)) bis (2 - ((2R, 4R, 6S) - 2 - 2-cyclopropyl-1 - 6 - metiltetrahidro - 2H - piran - 4-yl) - 2 - oxoetan - 2.1 - diyl) dicarbamato Dimethyl Or ((S, r, r, (1S, 2S) - (1S, 2S), 5S, 5S) - 5 - (5 - (1,1 - Diphenyl - [] - diyl bis (4,4) - 1H imidazole - 52 - diyl bis (2 -)) metilpirrolidin - 5.1 - diyl)) bis (1 - ((2S, 4R, 6R) - 6 - 2 - 2-cyclopropyl-1 - metiltetrahidro - 2H - piran - 4-yl) - 2 - oxoetan - 2.1 - diyl) dicarbamato Dimethyl ((S, R; S, 1S) - ((2S, 1S, 2S, 5S, 5S) - 5 - (5 - (1,1 - Diphenyl - [] - diyl bis (4,4) - 1H imidazole - 5.2 - diyl bis (2 -)) metilpirrolidin - 5.1 - diyl)) bis (2 - ((2R, 4S, 6S) - 2 - ciclopro Pil - 6 - metiltetrahidro - 2H - piran - 4-yl) - 2 - oxoetan - 2.1 - diyl) dicarbamato Dimethyl; (4),4 - bifenildiilbis (1h imidazole - 4.2 - diyl ((2S, 5S) - 5 - methyl - 2.1 - pirrolidindiil) (1 - (3 - cyano-3-phenoxybenzyl metilciclobutiliden) - 2 - oxo - 2.1 - dimethyl biscarbamato etandiil))); and (bifenildiilbis 4,4 - (1h imidazole - 4.2 - diyl ((2S, 5S) - 5 - methyl - 2.1 - pirrolidindiil) (1 - (3 - cyano-3-phenoxybenzyl metilciclobutiliden) - 2 - oxo - 2.1 - etandiil) biscarbama To Dimethyl; or a Salt of the pharmaceutical acceptable from the point of view.Claim 2 wherein: a compound is selected from: (bifenildiilbis 4,4 - (1h imidazole - 5.2 - diyl ((2S, 5R) - 5 - ethinyl - 2.1 - pirrolidindiil) ((1S) - 1 - ((2R, 4R) - 2.6 - dimetiltetrahidro - 2H - piran - 4-yl) - 2 - oxo - 2.1 - etandiil) biscarbamato) dimethyl (4.4); - bifenildiilbis (1h imidazole - 4.2 - diyl ((2S, 5S) - 5 - ethinyl - 2.1 - pirrolid
- 来源网站:
- 中国工程科技知识中心
- 来源网址:
- http://www.ckcest.cn/home/