Imidazole derivatives as inhibitors of hepatitis C virus

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专利权人:

BRISTOL-MYERS SQUIBB COMPANY

发明人:

MAKONEN BELEMA,ZHONG YANG,JOHN A. BENDER,DENIS R. ST. LAURENT,VAN N. NGUYEN,GAN WANG,JEFFREY LEE ROMINE

申请号：

ARP120104251

公开号：

AR088838A1

申请日:

2012.11.09

申请国别(地区):

AR

年份:

2014

代理人:

摘要：

Compounds, compositions and Methods for the treatment of infection by the hepatitis C virus (HCV). Also Pharmaceutical compositions containing such compounds and Methods of using such compounds in the treatment of hcv infection.Claim 1, characterized in that: a compound is selected from: (R, S, r, (1S, 2S) - (1S, 2S), 5S, 5S) - 5 - (5 - (1,1 - Diphenyl - [] - diyl bis (4,4) - 1H imidazole - diyl bis (5.2) 2 - metilpirrolidin - 5.1 - diyl)) bis (2 - ((2R, 4R, 6S) - 2 - 2-cyclopropyl-1 - 6 - metiltetrahidro - 2H - piran - 4-yl) - 2 - oxoetan - 2.1 - diyl) dicarbamato Dimethyl Or ((S, r, r, (1S, 2S) - (1S, 2S), 5S, 5S) - 5 - (5 - (1,1 - Diphenyl - [] - diyl bis (4,4) - 1H imidazole - 52 - diyl bis (2 -)) metilpirrolidin - 5.1 - diyl)) bis (1 - ((2S, 4R, 6R) - 6 - 2 - 2-cyclopropyl-1 - metiltetrahidro - 2H - piran - 4-yl) - 2 - oxoetan - 2.1 - diyl) dicarbamato Dimethyl ((S, R； S, 1S) - ((2S, 1S, 2S, 5S, 5S) - 5 - (5 - (1,1 - Diphenyl - [] - diyl bis (4,4) - 1H imidazole - 5.2 - diyl bis (2 -)) metilpirrolidin - 5.1 - diyl)) bis (2 - ((2R, 4S, 6S) - 2 - ciclopro Pil - 6 - metiltetrahidro - 2H - piran - 4-yl) - 2 - oxoetan - 2.1 - diyl) dicarbamato Dimethyl； (4),4 - bifenildiilbis (1h imidazole - 4.2 - diyl ((2S, 5S) - 5 - methyl - 2.1 - pirrolidindiil) (1 - (3 - cyano-3-phenoxybenzyl metilciclobutiliden) - 2 - oxo - 2.1 - dimethyl biscarbamato etandiil)))； and (bifenildiilbis 4,4 - (1h imidazole - 4.2 - diyl ((2S, 5S) - 5 - methyl - 2.1 - pirrolidindiil) (1 - (3 - cyano-3-phenoxybenzyl metilciclobutiliden) - 2 - oxo - 2.1 - etandiil) biscarbama To Dimethyl； or a Salt of the pharmaceutical acceptable from the point of view.Claim 2 wherein: a compound is selected from: (bifenildiilbis 4,4 - (1h imidazole - 5.2 - diyl ((2S, 5R) - 5 - ethinyl - 2.1 - pirrolidindiil) ((1S) - 1 - ((2R, 4R) - 2.6 - dimetiltetrahidro - 2H - piran - 4-yl) - 2 - oxo - 2.1 - etandiil) biscarbamato) dimethyl (4.4)； - bifenildiilbis (1h imidazole - 4.2 - diyl ((2S, 5S) - 5 - ethinyl - 2.1 - pirrolid

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