Ciclopentanocarboxilico Condensed acid derivatives useful as inhibitors of acylamino substituted with Receptor of endothelial differentiation gene 2 (edg-2) and their use as Farmaceutic ProductsOs
The present Invention relates to compounds that are valuable Pharmaceutical Active compounds such as acid, 2 - [4 - (methylsulfanyl - 3 - 2 - m-tolyl - ethoxy - benzoylamino)] - indan - 2 carboxylic acid.Specifically, are inhibitors of endothelial differentiation gene receptor 2 (edg-2, edg2), which is activated by Lyso phosphatidic acid (LPA) (LPA) and is also called lpa1 receiver,And are useful for the treatment of diseases such as atherosclerosis, Myocardial Infarction and heart failure, for example.The Invention also relates to processes for preparing the compounds of formula I, their use and Pharmaceutical compositions containing same.La presente invención se refiere a compuestos que son valiosos compuestos activos farmacéuticos, tal como el ácido 2-[4-metilsulfanil-3-(2-m-tolil-etoxi)-benzoilamino]-indano-2-carboxílico. Específicamente, son inhibidores del receptor del gen de diferenciación endotelial 2 (Edg-2, EDG2), que es activado por ácido lisofosfatídico (LPA) y también se denomina receptor LPA1, y son útiles para el tratamiento de enfermedades tales como aterosclerosis, infarto de miocardio e insuficiencia cardiaca, por ejemplo. La invención se refiere además a procedimientos para preparar los compuestos de fórmula I, a su uso y a composiciones farmacéuticas que los comprenden.
