4'- 4'-phosphopantetheinyl transferase enzyme inhibitors derived from Mycobacterium tuberculosis and pharmaceutical composition for use in preventing or treating tuberculosis containing the same as an active ingredient
The present invention relates to a 4'-phosphopantetheinyl transferase enzyme inhibitor derived from Mycobacterium tuberculosis and a pharmaceutical composition for preventing or treating tuberculosis containing the same as an active ingredient, according to the present invention. Compounds can significantly inhibit 4'-phosphopanthethenyl transferase enzyme to remove Mycobacterium tuberculosis through an immune response in the body, thereby having an effect that can be used for the prevention or treatment of tuberculosis.본 발명은 결핵균 유래의 4'-포스포판테테이닐 트랜스퍼레이즈(4'-phosphopantetheinyl transferase)효소 저해물질 및 이를 유효성분으로 함유하는 결핵의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명에 따른 화합물들은 4'-포스포판테테이닐 트랜스퍼레이즈 효소를 유의하게 저해하여 체내 면역반응을 통한 결핵균의 제거가 가능하고, 이를 통해 결핵의 예방 또는 치료에 사용될 수 있는 효과가 있다.
