A sphygmomanometer cuff assembly, air pump, pressure sensor and release valve are contained in an otherwise conventional computer mouse controller or are attached to a cell phone, television remote control or directly to a computer. In one embodiment the sphygmomanometer cuff is nominally positioned within a mouse structure and is extended outside the mouse housing during the measurement. In another embodiment, the cuff is always external of the mouse structure and is easily connected to the mouse at special ports during the measurement. In yet another embodiment, the cuff is always internal of the mouse structure and is readily accessible through an aperture in the housing surface of the mouse to permit the measurement to take place. In yet another embodiment, a wrist cuff and associated pump, sensor and valve are designed to be selectively connected to a cell phone to which appropriate software has been downloaded from a computer.