The new method and equipment of the principle of present disclosure are related to the waterproof exogenous material for efficient and targeted delivery, such as small molecule, protein, antibody and gene into cells, two in vitro and in vivo are to for drug, vaccine and the various treatment uses of gene delivery. Specifically, it is followed by scanning/space by conventional but intravitreous/subretinal injection gold nanorods and opsin plasmid with retina photodegeneration for vision restoration opsin patient the present invention is provided to the transmission of target nano reinforcement device and method optics and is matched by pathological regions and is determined for modulated laser beam and pass through funduscopy, OCT scan ophthalmoscope.
