Sven Ruf,Thorsten Sadowski,Klaus Wirth,Herman Schreuder,Christian Buning
申请号：
US14157703
公开号：
US09029559B2
申请日:
2014.01.17
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to compounds of the formula I,wherein A, D, E, L, G, R10, R30, R40, R50 and R60 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
