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A synthetic method of 3-carboxi-n-ethyl-n, n-dimethylpropane-1-amino acid salt for the treatment of cardiovascular diseases
专利权人:
JOINT STOCK COMPANY "GRINDEKS"
发明人:
KALVINS, IVARS,LIEPINS, EDGARS,LOZA, EINARS,DAMBROVA, MAIJA,STONANS, ILMARS,LOLA, DAINA,KUKA, JANIS,PUGOVICS, OSVALDS,VILSKERSTS, REINIS,GRINBERGA, SOLVEIGA
申请号:
PE2013002405
公开号:
PE20140777A1
申请日:
2012.04.27
申请国别(地区):
PE
年份:
2014
代理人:
摘要:
This is a process for the preparation of 3-carboxi-n-ethyl-n, n-dimethypropan-1-aminio salt, including (a) anadir n, n-dimethyphyl-4-oxo-1-butamine in acrylic acid or acetone and other solvents for the production of 4-ethoxy-n-ethyl bromide; (b) 4-ethoxy-n-ethyl bromide; N-dimethyl-4-oxo-1-butanamino obtains 4 - [ethyl (dimethyl) ammonium] butyric acid through an ionospheric exchange resin column; and (c) installs dienes, such as nicotinic acid, acidic organics and phosphates, in the solvent to obtain 3-carboxi-n-ethyl-n, n-dimethypropan-1-amine rilario salts; in these salts are (2e) - 3-carboxic,2,6-dioxo-1,2,3,6-tetrahydropirimidin-4-carboxilato and dihydrogenophase as an effective method for the treatment of ischemic heart disease such as myocardial infarctionSE REFIERE A UN PROCEDIMIENTO PARA PREPARAR UNA SAL DE 3-CARBOXI-N-ETIL-N,N-DIMETILPROPAN-1-AMINIO QUE COMPRENDE: A) ANADIR N,N-DIMETILETILAMINA AL 4-BROMOBUTANOATO DE ETILO EN UN DISOLVENTE TAL COMO ACETONITRILO O ACETONA PARA OBTENER BROMURO DE 4-ETOXI-N-ETIL-N,N-DIMETIL-4-OXO-1-BUTANAMINIO; B) HACER PASAR BROMURO DE 4-ETOXI-N-ETIL-N,N-DIMETIL-4-OXO-1-BUTANAMINIO A TRAVES DE UNA COLUMNA DE RESINA DE INTERCAMBIO IONICO PARA OBTENER BUTANOATO DE 4-[ETIL(DIMETIL)AMONIO]; Y C) ANADIR UN ACIDO TAL COMO ACIDO FUMARICO, ACIDO OROTICO Y ACIDO FOSFORICO EN UN DISOLVENTE PARA OBTENER LA SAL DE 3-CARBOXI-N-ETIL-N,N-DIMETILPROPAN-1-AMINIO; EN DONDE DICHAS SALES SON (2E)-3-CARBOXIACRILATO, 2,6-DIOXO-1,2,3,6-TETRAHIDROPIRIMIDIN-4-CARBOXILATO Y DIHIDROGENOFOSFATO, SIENDO UTILES EN EL TRATAMIENTO DE UNA CARDIOPATIA ISQUEMICA TAL COMO INFARTO DE MIOCARDIO
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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