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IMPROVED ANTIGEN BINDING RECEPTOR FORMATS
- 专利权人:
- F. HOFFMANN-LA ROCHE AG
- 发明人:
- KLEIN, Christian,MOESSNER, Ekkehard,DAROWSKI, Diana,STUBENRAUCH, Kay-Gunnar
- 申请号：
- SG11201908784T
- 公开号：
- SG11201908784TA
- 申请日:
- 2018.03.26
- 申请国别(地区):
- SG
- 年份:
- 2019
- 代理人:
- 摘要：
- INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) WIPO I PCT (51) International Patent Classification: A61K 39/395 (2006.01) C07K 14/735 (2006.01) (71) Applicant all designated States except US): F. HOFF- MANN-LA ROCHE AG [CH/CH]； Grenzacherstrasse A61K 35/17 (2015.01) C07K 16/28 (2006.01) 124, 4070 Basel (CH). C07K 14/725 (2006.01) C07K 16/30 (2006.01) C07K 14/705 (2006.01) A61K 39/00 (2006.01) (71) Applicant (for US only): HOFFMANN-LA ROCHE (21) International Application Number: INC. [US/US]； Overlook at Great Notch, 150 Clove Road, 8th Floor, Suite 8 - Legal Department, Little Falls, New Jer- PCT/EP2018/057567 sey 07424 (US). omit VIII °nolo olo VIII lII 1111111 ow (10) International Publication Number WO 2018/177967 Al (22) International Filing Date: 26 March 2018 (26.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 17163090.8 27 March 2017 (27.03.2017) EP 17171775.4 18 May 2017 (18.05.2017) EP (72) Inventors: KLEIN, Christian； c/o Roche Glycart AG, Wagistrasse 18, 8952 Schlieren (CH). MOESSNER, Ekke- hard； c/o Roche Glycart AG, Wagistrasse 18, 8952 Sch- lieren (CH). DAROWSKI, Diana； c/o Roche Glycart AG, Wagistrasse 18, 8952 Schlieren (CH). STUBENRAUCH, Kay-Gunnar； c/o Roche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg (DE). (74) Agent: BRODBECK, Michel； Grenzacherstrasse 124, 4070 Basel (CH). (54) Title: IMPROVED ANTIGEN BINDING RECEPTOR FORMATS Figure 1A Figure 1B Figure 1C linker VL CL linker VH VH CH CH VH CH ATM CSD SSD VL CL VL CL ATM CSD SSD ATM CSD SSD 1-1 N 1-1 00 1-1 O Fab Format Fab Format VL-CL-ATM scFab Format ATM = anchoring transmembrane domain； CSD = co-stimulatory signaling domain ； SSD = stimulatory signaling domain (57) : The present disclosure generally relates to antigen binding receptors in new formats capable of specific binding to a t
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
