KHAN, WAHID,SHIFRIN, HELENA,SCHLINGER, RON,AVRAMOFF, AVI,DOMB, AVI
申请号：
CA3035308
公开号：
CA3035308A1
申请日:
2017.08.30
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Embodiments of stable topical compositions for administering fenoldopam (compound (I) or a pharmaceutically acceptable salt or solvate thereof are disclosed for immediate or continued slow release administration, over prolonged periods of time with safe minimal systemic exposure of fenoldopam (reducing the risk for lowering blood pressure). The compositions include those compositions that increase the stability and skin absorption of the drug, particularly anhydrous semi-solid compositions and creams. This is accomplished by incorporating fenoldopam in soluble or dispersed form into semi-solid compositions like ointments or anhydrous gels that are not irritative. Embodiments of methods for using the topical compositions in the treatment of dermatological disorders including psoriasis, alopecia atopic dermatitis and vitiligo are disclosed.
