Michael O'Donnell;Joanne Pinder;David Kay;Thomas Cleveland;Jean-Damien Charrier;Haley Marie Binch;Steven John Durrant;Somhairle MacCormick;Lev ;Ronald Marcellus Alphonsus Knegtel;Stephen Clinton Young
发明人:
Jean-Damien Charrier,Steven John Durrant,David Kay,Michael O'Donnell,Ronald Marcellus Alphonsus Knegtel,Somhairle MacCormick,Joanne Pinder,Stephen Clinton Young,Haley Marie Binch,Thomas Cleveland,Lev,Michael ODonnell,Lev T
申请号：
US13104291
公开号：
US20120040020A1
申请日:
2011.10.27
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present disclosure relates to pyrazine compounds of formula I:wherein L, n, R1, and R2 are as described in the specification. These compounds are useful as inhibitors of ATR protein kinase. The disclosure also relates to pharmaceutically acceptable compositions comprising the compounds of the disclosure； methods of treating of various diseases, disorders, and conditions using the compounds of the disclosure； processes for preparing the compounds of the disclosure； intermediates for the preparation of the compounds of the disclosure； and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena； the study of intracellular signal transduction pathways mediated by such kinases； and the comparative evaluation of new kinase inhibitors.
