JENKINS, THOMAS E.,HUSFELD, CRAIG O.,SEROOGY, JULIE D.,WRAY, JONATHAN W.
申请号：
EP10815769
公开号：
EP2475429A4
申请日:
2010.04.21
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
Release is a kind of for, using the long-acting of competent pro-drug, providing being disclosed for the method narcoticness of a patient according to enzymatic activation and intramolecular cyclization with the narcoticness containing ketone containing ketone. The disclosure also provides such prodrug compound and pharmaceutical compositions including such compound. Such pharmaceutical compositions can optionally include a kind of enzyme inhibitor, with enzyme interacting with reconcile the slave pro-drug of the narcoticness containing ketone so as to modifying the enzyme of the enzymatic cleavage of pro-drug-it is long-acting. It furthermore include method to use such compound and pharmaceutical compositions.
