PANCOOK, James David,ROWLINSON, Scott William,STANCATO, Louis Frank
申请号：
PE2019002134
公开号：
PE20200385A1
申请日:
2018.04.20
申请国别(地区):
PE
年份:
2020
代理人:
摘要：
a. A protein, which is characterized by the presence of polypropylene, consists of a series of amino acids: stgskqrsqnrsktknqanqalmanvanensxaa33qrqqxaa37ckkyyvfr dlgwqdwiapxaa60gyaaxa65yegegegegecacafpnathna86a87qxa89lxaa91hxa93xa94npetvpkcpcatqa110a14yfdda120skva28a1nh134a1mxa3 (gc3d): xa3；Xa33 is d or m； xa37 is a or p； xa60 is e or Q； xa65 is y, s or G； xa86 is I, V, or L； xa87 is V or L； xa89 is t, s, or a； xa91 is V or m； xa93 is f or V； xa94 is I, f or m； xa1010 is g； Xa14 is V or m； xa20 is s or Q； xa128 is y, F, or W； 32 is Q, or XA1, Xa1134 is R or K, also refers to the process of cultivating stellar cells with expression vector containing nucleic acid, which transforms this protein or its protein into human morphine (BMP7)；A pharmaceutical synthesis including the protein or its variants and a carrier or diluent, and a second pharmaceutical synthesis including one or more chemotherapists' preparations, and a pharmaceutical for the treatment of cancer, Dano or cartilago, etc.Referido a una proteina caracterizada porque comprende un polipeptido que comprende una secuencia de aminoacidos: STGSKQRSQNRSKTPKNQEALRMANVAENSSSXaa33QRQXaa37CKKHELYVSFR DLGWQDWIIAPXaa60GYAAXaa65YCEGECAFPLNSYMNATNHAXaa86Xaa87QXaa89LXaa91HXaa93Xaa94NPETVPKPCCAPTQLXaa110AISXaa114LYFDDXaa120SNVILKKXaa128RNMXaa132VXaa134ACGCH (SEQ ID NO: 3)； en donde Xaa33 es D o M； Xaa37 es A o P； Xaa60 es E o Q； Xaa65 es Y, S, o G； Xaa86 es I, V, o L； Xaa87 es V o L； Xaa89 es T, S, o A； Xaa91 es V o M； Xaa93 es F o V； Xaa94 es I, F o M； Xaa110 es G； Xaa114 es V o M； Xaa120 es S o Q； Xaa128 es Y, F o W； Xaa132 es V, Q, o S； y, Xaa134 es R o K. Tambien se refiere a un proceso de cultivar una celula hospedera transformada con un vector de expresion que contiene un acido nucleico que codifica dicha proteina o su variante de proteina morfogenica osea humana (BMP7)； un kit que comprende una composicion farmaceutica que contiene dicha proteina o su variante y un portador o diluyente, y una segunda composicion fa
