Long chain omega-3 and omega-6 polyunsaturated fatty acid biosynthesis by expression of acyl-CoA lysophospholipid acyltransferases

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专利权人:

Narendra S. Yadav

发明人:

Narendra S. Yadav,Hongxiang Zhang,Quinn Qun Zhu

申请号：

US12814764

公开号：

US08524485B2

申请日:

2010.06.14

申请国别(地区):

US

年份:

2013

代理人:

摘要：

Methods for increasing C18 to C20 elongation conversion efficiency and/or Δ4 desaturation conversion efficiency in long-chain polyunsaturated fatty acid [“LC-PUFA”]-producing recombinant oleaginous microbial host cells are provided herein, based on over-expression of acyl-CoA:lysophospholipid acyltransferases [“LPLATs”] (e.g., Ale1, LPAAT, LPCAT). Production host cells and oils produced by the methods of the invention are also claimed.

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