Dennis T. Brown,Raquel Hernandez,Malcolm E. Thomas,Katherine M. Smith
申请号：
US13069905
公开号：
US10081795B2
申请日:
2011.03.23
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Methods and compositions concerning mutant flaviviruses with host range mutations. In some embodiments the invention concerns nucleotide sequences that encode mutant flavivirus proteins. Viruses comprising these sequences that display reduced replication in mammalian cells are provided. In further aspects of the invention, flavivirus vaccine compositions are provided. In another embodiment the invention provides methods for vaccination against flavivirus infection.
