Disclosed are methods of enhancing regeneration of the nucleus pulposus through enhancement of perispinal perfusion in combination with a regenerative intervention. In one embodiment the invention teaches stimulation of enhancement of perispinal perfusion by administration of angiogenic agents prior to performing a regenerative intervention such as administration of a stem cell therapy. In one specific embodiment perispinal angiogenesis is stimulated by administration of autologous bone marrow mononuclear cells in the perispinal area, preferably into a muscular area, subsequent to which intradiscal administration of regenerative cells, such as mesenchymal stem cells is performed.
