A kind of endoparasitic composition includes emodepside and praziquantel or epsiprantel. The solvent of the composition is 1,2-isopropylideneglycerol solketal (one) moisture at most 1%. The composition solves the hydrolysis of 1,2-isopropylidene ethylene glycol to form acetone by guaranteeing water content lower than 1%. It also discloses preparation the composition and is used to control the purposes of the drug of entozoa using the composition.Det er beskrevet sammensetninger som kan påføres eksternt, omfattende emodepsid og prazikvantel eller epsiprantel og også 1,2-isopropylidenglyserol, deres fremstilling og deres anvendelse for å kontrollere endoparasitter.