NOVEL PHOSPH(ON)ATE- AND SULF(ON)ATE-BASED PHOSPHATE MODIFIED NUCLEOSIDES USEFUL AS SUBSTRATES FOR POLYMERASES AND AS ANTIVIRAL AGENTS

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专利权人:

Piet Herdewijn

发明人:

Piet Herdewijn,Philippe Marlière

申请号：

US13514007

公开号：

US20120245029A1

申请日:

2010.05.12

申请国别(地区):

US

年份:

2012

代理人:

摘要：

This invention provides phosphate-modified nucleosides represented by the structural formula (I): wherein W is O or S, and wherein B, R1 R3 and R2. are as defined herein. These compounds are useful as substrates for DNA/RNA polymerases, and as anti-viral agents in particular against HIV-1.

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