Jason Allan Wiles,Qiuping Wang,Akihiro Hashimoto,Godwin Pais,Xiangzhu Wang,Venkat Gadhachanda,Avinash Phadke,Milind Deshpande,Dawei Chen
申请号：
US14972913
公开号：
US09474742B2
申请日:
2015.12.17
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present disclosure provides substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes, of Formula ID-M-D (Formula I)useful as antiviral agents. In certain embodiments disclosed herein M is a group —P-A-P— where A isCertain substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes disclosed herein are potent and/or selective inhibitors of viral replication, particularly Hepatitis C virus replication. Pharmaceutical compositions/and combinations containing one or more substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes and a pharmaceutically acceptable carrier are also provided by this disclosure. Methods for treating viral infections, including Hepatitis C viral infections are provided by the disclosure.
