ZHAO, Tao,ZHANG, Huihui,YANG, Shuai,ZHANG, Yun,CHOU, Chuan-Chu,WU, Shu
申请号：
SG11202006877P
公开号：
SG11202006877PA
申请日:
2019.01.24
申请国别(地区):
SG
年份:
2020
代理人:
摘要：
Provided are antibodies including monoclonal, human, primate, rodent, mammalian, chimeric, humanized and CDR-grafted antibodies, and antigen binding fragments and antigen binding derivatives thereof. These antibodies bind to CD47 protein, particularly human CD47, modulate, e.g., inhibit, block, antagonize, neutralize or otherwise interfere with CD47 expression, activity and/or signaling, including inhibiting CD47 and SIRPa interaction； do not cause a significant level of hemagglutination of human red blood cells. These antibodies may not enhance RBC phagocytosis.
