Children's Hospital Medical Center;The Trustees of Columbia University
发明人:
DEVARAJAN, Prased,BARASCH, Jonathan
申请号：
ES04758356
公开号：
ES2330005T5
申请日:
2004.03.26
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A method and kit for detecting the early onset of renal tubular cell injury, utilizing NGAL as an early urinary biomarker. NGAL is a small secreted polypeptide that is protease resistant and consequently readily detected in the urine following renal tubule cell injury. NGAL protein expression is detected predominantly in proximal tubule cells, in a punctate cytoplasmic distribution reminiscent of a secreted protein. The appearance NGAL in the urine is related to the dose and duration of renal ischemia and nephrotoxemia, and is diagnostic of renal tubule cell injury and renal failure. NGAL detection is also a useful marker for monitoring the nephrotoxic side effects of drugs or other therapeutic agents.
