Eckard Wimmer,Steve Skiena,Steffen Mueller,Bruce Futcher,Dimitris Papamichail,John Robert Coleman,Jeronimo Cello
申请号：
US13501045
公开号：
US20120269849A1
申请日:
2010.10.11
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present provides attenuated influenza viruses comprising a modified viral genome containing a plurality of nucleotide substitutions. The nucleotide substitutions result in the rearrangement of preexisting codons of one or more protein encoding sequences and changes in codon pair bias. Substitutions of non-synonymous and synonymous codons may also be included. The attenuated influenza viruses enable production of improved vaccines and are used to elicit protective immune responses.
