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PROCESS FOR THE PREPARATION OF A SOLID DOSAGE FORM, IN PARTICULAR A TABLET, FOR PHARMACEUTICAL USE AND PROCESS FOR THE PREPARATION OF A PRECURSOR FOR A SOLID DOSAGE FORM, IN PARTICULAR A TABLET
专利权人:
发明人:
FAURE, ANNE,法瑞 安妮,法瑞 安妮,VOORSPOELS, JODY FIRMIN MARCELINE,福尔斯柏斯 裘蒂 芙明 马可兰,福爾斯柏斯 裘蒂 芙明 馬可蘭,MERTENS, ROEL JOS M.,梅尔顿斯 罗尔 裘斯 明,梅爾頓斯 羅爾 裘斯 明,其肯斯 菲利浦 芮内 依芮娜,其肯斯 菲利浦 芮內 依芮娜
申请号:
TW098115226
公开号:
TWI524904B
申请日:
2009.05.08
申请国别(地区):
TW
年份:
2016
代理人:
摘要:
The present invention refers to a process for preparing a powder comprising the steps of providing at least one first component being in liquid form at ambient temperature, in particular having a viscous liquid consistency, such as for example an oil or having a waxy consistency at ambient temperature, in particular a component which is a solid or semi-solid at ambient temperature and which has an onset of melting in the temperature range from 15℃ to 40℃ providing at least one second component having a melting point or melting range in the range from above ambient temperature to below the degradation temperature of said first component, in particular in the range from above ambient temperature to 120℃, more in particular in the range from >40℃ to 120℃, even more in particular in the range from 50℃ to 120℃, even further in particular in the range from 55℃ to 120℃, forming a homogenous liquid mixture comprising said at least one first component and said at least one second component by stirring and heating the mixture to or keeping the mixture at a temperature in the range from above the meting point or melting range of said second component and below the degradation temperature of said first component, in particular in the range from above the melting point or melting range of said second component to 120℃, transferring the liquid mixture to at least one spray congealing unit by at least one transfer unit, which is adapted to keep the mixture in its liquid form during its transfer, spray congealing said mixture, and isolating the powder obtained upon spray congealing. Further, the present invention refers to a process for the preparation of a solid dosage form comprising the powder resulting from the above process.本發明係關於一製備粉末之方法,該方法之步驟包含提供至少一第一成份物質,其於常溫下形式為液體,尤其具黏稠液體之濃稠度,例如一油性物質;或具於常溫下蠟之濃稠度,尤其一成份物質,其於常溫下為固體或半固體,且其開始熔化之溫度範圍介於15℃至40℃之間;提供至少一第二成份物質,其具介於高於常溫之熔點或熔點範圍,至低於所述第一成份物質之分解溫度之範圍之間,尤其介於高於常溫至120℃之範圍之間,更加特別為介於>40℃至120℃之範圍之間,甚至更特別為介於50℃至120℃之範圍之間,甚至又更特別為介於55℃至120℃之範圍之
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