Crespo, Maria Isabel Crespo,Romero, Eloisa Navarro,Duran, Carlos Puig,Roig, Silvia Gual,Laria, Julio Cesar Castro Palomino
申请号：
NO20076498
公开号：
NO339984B1
申请日:
2007.12.18
申请国别(地区):
NO
年份:
2017
代理人:
摘要：
The present invention provides a compound of formula (I): wherein: €¢ R 1 is a group selected from -CH 2 OH, -NHC(O)H and €¢ R 2 is a hydrogen atom or €¢ R 1 together with R 2 form the group -NH-C(O)-CH=CH- wherein the nitrogen atom is bound to the carbon atom in the phenyl ring holding R 1 and the carbon atom is bound to the carbon atom in the phenyl ring holding R 2 €¢ R 3 is selected from hydrogen and halogen atoms or groups selected from -SO-R 5 , -SO 2 -R 5 , -NH-CO-NH 2 , -CO-NH 2 , hydantoino, C 1-4 alkyl, C 1-4 alkoxy and -SO 2 NR 5 R 6 €¢ R 4 is selected from hydrogen atoms, halogen atoms and C 1-4 alkyl groups €¢ R 5 is a C 1-4 alkyl group or C 3-8 cycloalkyl €¢ R 6 is independently selected from hydrogen atoms and C 1-4 alkyl groups €¢ n, p and q are independently 0, 1, 2, 3 or 4 €¢ m and s are independently 0, 1, 2 or 3 €¢ r is 0, 1 or 2 with the provisos that: €¢ at least one of m and r is not 0 €¢ the sum n+m+p+q+r+s is 7, 8, 9, 10, 11, 12 or 13 €¢ the sum q+r+s is 2, 3, 4, 5 or 6 or a pharmaceutically-acceptable salt, solvate or stereoisomer thereof.
