Compounds, Compositions and Methods of Inhibiting Alpha-Synuclein Toxicity

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专利权人:

WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH

发明人:

LINDQUIST, SUSAN L

申请号：

NZ58843205

公开号：

NZ588432A

申请日:

2005.09.16

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

Disclosed are compounds represented by general formula (I), wherein X is O, S or NR, and R25 and R26 together form a heterocyclyl or heteroaryl ring. Also disclosed is the use of the compounds of formula (I) for inhibiting or preventing alpha-synuclein toxicity and/or fibril formation, inhibiting or preventing alpha-synuclein fibril growth, and/or causing disassembly, disruption, and/or disaggregation of alpha-synuclein fibrils and alpha-synuclein-associated protein deposits.

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