COMPOSES DE DEGRADATION/PERTURBATION DE LA PROTEINE ARGININE METHYLTRANSFERASE 5 (PRMT5) ET METHODES D'UTILISATION

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专利权人:

ICHAN SCHOOL OF MEDICINE AT MOUNT SINAI

发明人:

JIN, JIAN,LIU, JING,SHEN, YUDAO,GUCCIONE, ERNESTO,WALSH, MARTIN,BOSCH, ALMUDENA,SCHWARZ, MEGAN

申请号：

CA3091041

公开号：

CA3091041A1

申请日:

2019.02.22

申请国别(地区):

CA

年份:

2019

代理人:

摘要：

Disclosed are protein arginine methyltransferase 5 (PRMT5) degradation / disruption compounds including a PRMT5 ligand, a degradation / disruption tag and a linker, and methods for use of such compounds in the treatment of PRMT5-mediated diseases. The PRMT5 degraders disclosed herein offer a novel mechanism for treating PRMT5-mediated diseases compared to small molecule inhibitors of PRMT5 activity.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/