Johannes A. G. Van Strijp;Petrus J. A. Haas;Christina Furebring;Anna Rosen;Cornelis P. M. Van Kessel;Karin Haraldsson;Erika Gustafsson;Lena Schultz
发明人:
Christina Furebring,Johannes A. G. Van Strijp,Petrus J. A. Haas,Anna Rosen,Karin Haraldsson,Erika Gustafsson,Lena Schultz,Cornelis P. M. Van Kessel
申请号：
US12297860
公开号：
US08173774B2
申请日:
2007.04.20
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides a polypeptide having a biological activity of the Chemotaxis Inhibitory Protein of Staphylococcus aureus (‘CHIPS’), the polypeptide comprising a variant of the amino acid sequence of SEQ ID NO:1. Preferably, the polypeptide is a CHIPS variant wherein one or more of the following amino acids is modified: N31, S32, G33, L34, P35, K40, D42, R46, Y48, K50, G52, T53, K54, N55, S56, A57, Q58, K61, E67, K69, L76, N77, P79, D83, L90, K92, K100, K101, S104, K105, S107, Y108, N111 and G112. In a preferred embodiment, the polypeptide is less immunogenic hi humans than the wildtype CHIPS protein. The invention further provides methods of making and using such variant CHIPS polypeptides.
