The present invention provides for an animal medicine reminder tag that is non-toxic, water resistant, and shock resistant. The tags described herein are excellent medicine compliance tools as they 1) are automatically activated when attached to the companion animal 2) produce a persistent reminder after a manufacturer-programmed set period of time 3) cannot be reset or turned off by the companion animals caregiver 4) emit the alarm/signal from both sides 5) are sealed and non-toxic and 6) are designed to be minimally harmful if accidentally swallowed, and may even pass safely through the gastro-intestinal tract for sufficiently large animals.