This invention relates to a medicament filling and dispensing device, comprising a medicament container, a perfusing device, a transporting pipeline, a filtering membrane device, and a dispensing needle, wherein the dispensing has a tip that has a smooth and sharp shape and pierces into a plug disposed on the medicament container. The dispensing needle has therein a passageway of which an outlet at one end is located on a side wall surface of the dispensing needle. The side wall surface of the dispensing needle comprises an air guiding groove formed therein. Since the opening of the passageway is located on the side wall surface of the dispensing needle, when the dispensing needle pierces into the plug, there is no doubt about scrap of the plug generated to drop into the medicament container. When the pressure inside the medicament container gradually increases along with the introduction of the medicament therein, the air and pressure inside the medicament container can be discharged through the air guiding groove so as to enhance the smoothness of a medicament filling process and protect the medicament from outside contamination.本發明為一種藥劑充填分注裝置,其包括有一藥劑容器、一灌注裝置、一輸送管線、一過濾膜裝置及一分注針,其中該分注針之尖端呈光滑尖狀且穿入於藥劑容器上所設塞體中,該分注針之內部具有一流道,該流道的一端出口位於分注針之側壁面上,且於分注針之側壁面上設有導氣槽;由於流道開口位於分注針之側壁面上,在分注針穿入塞體時,不會產生塞體碎屑掉入藥劑容器中之疑慮,在藥劑容器內部壓力隨藥劑注入逐漸上升時,可透過該導氣槽排出藥劑容器內部空氣及壓力,藉此增進藥劑充填過程之順暢,並確保藥劑不受外界汙染。10‧‧‧藥劑容器11‧‧‧塞體41‧‧‧流道42‧‧‧側向開口