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FEXOPHENADINE MICROCapsules AND THEIR COMPOSITIONS
专利权人:
Апталис Фарма Лимитед (IE)
发明人:
МАПЕЛЛИ Луиджи (IT),ФАБИАНИ Флавио (IT),БОЛЬТРИ Луиджи (IT),ГАТТИ Паоло (IT),СЕРРАТОНИ Мауро (IT),КАССАНМАНЬЯГО Роберто (IT)
申请号:
RU2012124262/15
公开号:
RU2012124262A
申请日:
2010.12.01
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A pharmaceutical composition comprising microcapsules selected from taste-masked immediate-release microcapsules or co-granulated taste-masked immediate-release microcapsules and mixtures thereof, wherein said microcapsules contain fexofenadine and a water-insoluble polymer coating. The pharmaceutical composition of claim 1, wherein said microcapsules are co-granulated, immediate-release, microcapsules with a masked taste. The pharmaceutical composition according to claims 1 and 2, wherein said fexofenadine is fexofenadine hydrochloride. 4. The pharmaceutical composition according to claim 1, wherein said water-insoluble polymer is selected from the group consisting of ethyl cellulose, polyvinyl acetate, cellulose acetate, cellulose acetate butyrate, polyvinyl acetate, ammonium-methacrylate copolymers and mixtures thereof. The pharmaceutical composition according to claim 1, wherein the weight of the water-insoluble polymer of said microcapsules is from about 2% to about 40%. The pharmaceutical composition according to claim 3, wherein said composition releases at least about 60% of said fexofenadine hydrochloride within 15 minutes in a liquid with a pH of 6.8 according to the 2nd edition of the Japanese Pharmacopoeia. The pharmaceutical composition of claim 1, wherein said microcapsules further comprise a surfactant. The pharmaceutical composition according to claim 7, wherein said microcapsules further comprise a glidant or tackifier. The pharmaceutical composition according to claim 1, additionally containing at least one inactive ingredient,1. Фармацевтическая композиция, содержащая микрокапсулы, выбранные из микрокапсул немедленного высвобождения с замаскированным вкусом или совместно гранулированных микрокапсул немедленного высвобождения с замаскированным вкусом и их смесей, где указанные микрокапсулы содержат фексофенадин и нерастворимое в воде полимерное покрытие.2. Фармацевтическая композиция по п.1, где указанные микрокапсулы являются совместно гранулир
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中国工程科技知识中心
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