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PROCÉDÉ DE FABRICATION DE STRUCTURE ANALOGUE À LA ZONE MARGINALE CILIAIRE
专利权人:
SUMITOMO CHEMICAL COMPANY, LIMITED;RIKEN
发明人:
申请号:
EP19165595.0
公开号:
EP3524671A1
申请日:
2014.10.16
申请国别(地区):
EP
年份:
2019
代理人:
摘要:
The present invention provides a method for producing a cell aggregate containing a ciliary marginal zone-like structure, including a step of culturing a cell aggregate containing a retinal tissue in which Chx10 positive cells are present in a proportion of 20% or more and 100% or less of the tissue in a serum-free medium or serum-containing medium each containing a substance acting on the Wnt signal pathway and a substance inhibiting the FGF signal pathway for only a period before the appearance of a RPE65 gene expressing cell, followed by culturing the "cell aggregate in which a RPE65 gene-expressing cell does not appear" thus obtained in a serum-free medium or serum-containing medium each free of a substance acting on the Wnt signal pathway and so on. According to the production method of the present invention, a ciliary marginal zone-like structure can be produced with high efficiency.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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