Yasmin A. CHANDRASEKHER;Anthony W. SIADAK;Wenfeng XU;Wayne KINDSVOGEL;Margaret Dow MOORE;Joyce M. LEHNER;Pallavur V. SIVAKUMAR;Stacey R. DILLON
发明人:
Wenfeng XU,Wayne KINDSVOGEL,Yasmin A. CHANDRASEKHER,Stacey R. DILLON,Joyce M. LEHNER,Anthony W. SIADAK,Pallavur V. SIVAKUMAR,Margaret Dow MOORE
申请号：
US13427077
公开号：
US20120207761A1
申请日:
2012.03.22
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-22, IL-20, or both IL-20 and IL-22 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. IL-22RA (zcytor11) is a common receptor for IL-20 and IL-22. The present invention includes anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-22 or both IL-20 and IL-22 using such antibodies and binding partners.
