#$%^&*AU2012211437B220150820.pdf#####ABSTRACT The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function as a consequence of one or more amino acid modifications in the Fc region thereof. 3574841_1 (GHMaetrs) P42652.AU.3 8-Aug- 12