Shanghai Hengrui Pharmaceutical Co., Ltd.;Jiangsu Hengrui Medicine Co., Ltd.
发明人:
Fanglong YANG,Weimin WANG,Xiaodong LI,Gang CHEN,Feng HE,Weikang TAO
申请号：
US16804180
公开号：
US20200199115A1
申请日:
2020.02.28
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to an oxopicolinamide derivative, a preparationmethod therefor and the pharmaceutical use thereof. In particular, the present invention relates to an oxopicolinamide derivative as shown in the general formula (AI), a preparation method therefor and a pharmaceutical composition comprising the derivative, and to the use thereof as a therapeutic agent, in particular as an inhibitor of blood coagulation factor XIa (Factor XIa, FXIa for short) and the use thereof in the preparation of a drug for treating diseases such as thromboembolism, wherein the definition of each substituent in the general formula (AI) is the same as defined in the description.
