The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for example through binding to a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein (e.g., a eukaryotic target protein such as a mammalian target protein or a fungal target protein or a prokaryotic target protein such as a bacterial target protein). These compounds bind endogenous intracellular presenter proteins, such as the FKBPs or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of intracellular target proteins. Formation of a tripartite complex among the presenter protein, the compound, and the target protein is driven by both protein-compound and protein-protein interactions, and both are required for modulation of the targeted proteins activity. In some embodiments, the compounds of the invention "re-program" the binding of the presenter proteins to protein targets that either do not normally bind to the presenter protein (e.g., do not show detectable binding in mammalian cells absent the compound). In some embodiments, provided compounds "re-program" presenter protein binding to greatly enhance interaction with a particular target with which it may have some interaction absent the compound. Interactions achieved through such reprogramming result in an ability to modulate the activity of these new targets.Linvention concerne des composés (par exemple des composés macrocycliques) capables de moduler des processus biologiques, par exemple par liaison à une protéine présentatrice (par exemple faisant partie de la famille des FKBP, de la famille des cyclophilines, ou PIN1) et à une protéine cible (par exemple une protéine cible eucaryote telle quune protéine cible de mammifère ou une protéine cible fongique ou une protéine cible procaryote telle quune protéine cible bactérienne). Ces composés se lient à des protéines présentatrices intracellulaires
